1 One approach towards selective modulation of dopamine signaling in the PFC is by inhibition of catechol O-methyltransferase (COMT), which is the predominant means of dopamine clearance in the PFC because of the lack of expression of synaptic dopamine transporters in this region, 2 in contrast to the striatum.ĬOMT is a magnesium-containing metalloenzyme that transfers a methyl group from the cofactor S-adenosylmethionine (SAM) to a number of endogenous and exogenous catechols such as dopamine, catecholestrogens, and dietary polyphenols.
Proper functioning of dopamine signaling in the prefrontal cortex (PFC) is critical for a number of cognitive and behavioral processes that are impaired in a variety of conditions such as ADHD, obsessive-compulsive disorder, traumatic brain injury, and schizophrenia.
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